4-Dimethylaminopyridine (DMAP)

4-Dimethylaminopyridine-type high-efficiency acylation catalysts and core raw materials for the pharmaceutical and pesticide industries

Product Information


  • 产品名 4-Dimethylaminopyridine (DMAP)
  • 化学式 C₇H₁₀N₂
  • CAS 1122-58-3
  • 执行标准 Q/XTD06.7-2021
  • 产品特性 White to off-white crystalline powder
  • 产品包装 25kg/drum

Product Overview and Characteristics

This product is widely used in the field of organic synthesis and is known as a “super catalyst.” It is mainly used to catalyze acylation, esterification, transesterification, and other reactions, especially in the acylation of sterically hindered alcohols and amines, where its catalytic efficiency is extremely high, with activity approximately 10⁴ to 10⁶ times that of pyridine. In the pharmaceutical industry, it is used in the production of active pharmaceutical ingredients such as statin lipid-lowering drugs and acetyl(propionyl)spiramycin. In fields such as pesticides, dyes, and fragrances, it is also widely used in various synthetic reactions. Typically, the catalyst dosage is only 0.01% to 5% of the molar amount of the reaction substrate, and the reaction conditions are mild with high yield.

High-efficiency acylation catalyst

Used as a high-efficiency acylation catalyst in organic synthesis, with catalytic activity approximately 10,000 to 1,000,000 times that of pyridine. It is especially suitable for the acylation of sterically hindered alcohols and amines. Typically, the catalyst dosage is only 0.01% to 5% of the molar amount of the reaction substrate, and the reaction conditions are mild with high yield.

Pharmaceutical industry

Used in the production of active pharmaceutical ingredients such as statin lipid-lowering drugs and acetyl(propionyl)spiramycin, and is an important organic synthesis catalyst in the pharmaceutical industry.

Pesticides and fragrances

In fields such as pesticides, dyes, and fragrances, it is widely used in various acylation, esterification, transesterification, and other reactions to improve reaction efficiency and product purity.

Mild reaction conditions

Mild reaction conditions and simple operation, widely used in laboratory research and industrial production, with characteristics such as low dosage and high catalytic efficiency.